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Tapentadol is a powerful analgesic that provides relief from moderate to severe pain. Tapentadol works by inhibiting the reuptake of norepinephrine, serotonin and dopamine in the brain. This allows tapentadol to have a strong anti-depressant effect as well. tapentadol can also be used as adjuvant therapy for patients with chronic musculoskeletal pain who are not responding adequately to treatment with non-opioid analgesics or antidepressants alone. tapentadol has been approved for use in Europe since 1997 and was approved in America only recently, under the trade name Nucynta (tapentadol).


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Research that has been conducted on mice has shown some validity in possibly using the drug for treating the symptoms of depression, however, the doctors do not believe that it can be used as an anti-depressant unless it is needed in such cases when the other depression meds that are given have failed.

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